GU LAB - 生物制造研究组

顾奇实验室

生物制造研究组

希望来到这里之后能够继续成长：

批判思考之习惯，钻研刻苦之精神，辩证分析之能力；
追求卓越之信心，积极包容之态度，恪守公正之素养。

近期动态

Tissue Engineering & Regenerative Medicine International Society – Asia-Pacific Chapter Conference (TERMIS-AP 2026), Christchurch, New Zealand
2026年国际组织工程与再生医学学会亚太分会学术会议，新西兰基督城
Session 7E: Biofabrication, Bioprinting & Engineered Tissue Constructs
专题论坛7E：生物制造、生物打印与工程化组织构建
Session 4G: Organoids, Spheroids & Organ-on-Chip Systems
专题论坛4G：类器官、细胞球与器官芯片系统
Engineering Physiological Structure through Multilevel Biofabrication
基于多层级生物制造的生理结构工程化构建
Prof. Qi Gu, Session Chair (7E) and Keynote Speaker (4G)

GU LAB at the 9th CAS Science Festival
On October 31 – November 1, 2026, GU LAB participated in the 9th Science Festival hosted by the Chinese Academy of Sciences at the National Botanical Garden (South Garden), Beijing. Under the theme “Fun with 3D Printing,” our team brought cutting-edge biofabrication technologies to life through interactive demonstrations, hands-on experiments, and engaging science activities.

Highlights included:

3D Printing Showcase: Live demonstrations of FDM and CELLINK bioprinting systems illustrated how digital designs are transformed into physical structures, introducing visitors to the principles of additive manufacturing.
Hands-on Experiments: Non-Newtonian “magic mud” made from cornstarch and water allowed children to experience the fascinating behavior of materials that respond differently to slow and rapid forces.
Bioprinting and Organ Fabrication: Through live demonstrations, tissue models, images, and videos, visitors explored how bioinks and living cells can be used to construct engineered tissues, highlighting advances and challenges in regenerative medicine.
Microfluidics Demonstration: Visitors observed microsphere generation using microfluidic chips, discovering how fluids can be precisely manipulated at the microscale for biomedical applications.
Interactive Activities: Science quizzes, stamp-collecting games, prize draws, and fingerprint tree activities encouraged curiosity and creativity, while 3D-printed souvenirs brought a little piece of science home.

The two-day event offered children and families an opportunity to explore science beyond textbooks and experience the excitement of scientific discovery firsthand. Through these activities, GU LAB continued its commitment to making advanced research in biofabrication, tissue engineering, and regenerative medicine accessible to the public, inspiring the next generation of curious minds and future scientists.

2026 International Conference on Additive Manufacturing and Bio-Manufacturing (ICAM-BM 2026), Beijing
2026国际增材制造与生物制造会议，北京
Session: Biomanufacturing for Organoids, Organ-on-Chips and Microphysiological Systems
专题论坛：面向类器官、器官芯片与微生理系统的生物制造

Nanoengineered Extrusion-Aligned Tract Bioprinting Enables Functional Repair of Spinal Cord Injuries
纳米工程化挤出定向束状生物打印促进脊髓损伤功能修复
Dr. Wenhui Huang, Oral Presenter

Multiscale Bioassembly and Fabrication of Physiological Structures
多尺度生理结构组装与制造
Prof. Qi Gu, Session Co-Chair and Keynote Speaker

We are excited to share that our review, “Advancing Stem Cell Bioprinting to Bridge Engineered and Natural Tissue Constructs,” has been featured on the back cover of Advanced Materials (Volume 38, Issue 42).

In this review, we summarize recent progress in stem-cell-based organ manufacturing and highlight strategies for developmentally inspired tissue fabrication. By integrating intrinsic cellular programs, including genetic networks and self-organization, with extrinsic engineering cues such as bioink dynamics, microfabrication, and mechanical regulation, we propose a conceptual framework that brings instructive bioprinting together with autonomous development.

The cover depicts stem-cell biomanufacturing as a vibrant “Life Tree.” The DNA-helix trunk, robotic bioprinter, and hydrogel-rooted living bioinks symbolize the convergence of biological programming and precision fabrication, while the organ-like canopy illustrates stem-cell self-organization, maturation, and functional tissue formation. Together, these elements envision a path toward bridging engineered tissue constructs with natural regeneration.

Stem Cell-Based Biomanufacturing: The Life Tree

We are excited to share that our study, “Cryopreservative Bioink Enables Direct Bioprinting of Adherent Cells,” has been featured on the cover of Advanced Materials (Volume 38, Issue 40).

In this work, we developed CAMP (Cryopreservation for Adhesion and Maintenance Printing), a DMSO-free bioink platform that preserves adherent cells during liquid nitrogen storage and enables direct 3D bioprinting at 4–8°C after thawing. By inhibiting ice recrystallization and maintaining cell adhesion, CAMP achieves approximately 80% cell viability and integrates cryopreservation, bioprinting, and functional tissue formation into a streamlined workflow. In a rat femoral defect model, cryopreserved CAMP constructs promoted complete bone regeneration within three months.

The cover depicts snow-covered mountains and glaciers as the cryogenic environment, while bioprinted tissues emerge as wintersweet blossoms. Inspired by the resilience of wintersweet blooming through the bitter cold, the artwork illustrates how cryopreserved cells can develop into robust and functional tissues through precise bioprinting. This work advances on-demand biofabrication toward ready-to-use and clinically applicable engineered tissues.

PhD Dissertation Defense
Wenhui Huang, Kai Li, and Tan Jia have successfully defended their doctoral dissertations. Congratulations on your graduation and best wishes for your next adventure, Dr. Huang, Dr. Li, and Dr. Jia!
Master’s Thesis Defense
Congratulations to our graduate students, Haolin Chen and Shuxian Chen!

We are excited to share that our latest study, “Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries,” has been selected as a cover article in Cell Stem Cell.
In this work, we introduce a nanoengineered bioprinting strategy that harnesses shear forces during extrusion to generate continuous, hierarchically aligned tissue tracts—spanning from nanoscale collagen fibrils to centimeter-scale constructs—without post-processing. This platform enables precise guidance of neural cells and axons, and demonstrates robust functional recovery in spinal cord injury models. The cover highlights a new paradigm in biofabrication for building anisotropic, regenerative tissues with clinically relevant dimensions.

Qi Gu Follow

顾奇实验室

生物制造研究组

近期动态

ConferenceOctober 27, 2026 - October 30, 2026

EventOctober 31, 2026 - November 1, 2026

ConferenceOctober 13, 2026 - October 15, 2026

PublicationJuly 28, 2026

PublicationJuly 17, 2026

PhD Dissertation Defense & Master’s Thesis DefenseMay 13, 2026

PublicationFebruary 6, 2026

挑战不可能

Conference
October 27, 2026 - October 30, 2026

Event
October 31, 2026 - November 1, 2026

Conference
October 13, 2026 - October 15, 2026

Publication
July 28, 2026

Publication
July 17, 2026

PhD Dissertation Defense & Master’s Thesis Defense
May 13, 2026

Publication
February 6, 2026